Protein Biochemistry Scientist/Investigator: Oncology Drug Discovery

The Biological Chemistry group within Oncology Drug Discovery is focused on understanding and exploiting the molecular mechanisms of novel cancer targets for the discovery, characterization and optimization of small molecule therapeutics. We are seeking a highly motivated, creative and collaborative protein biochemist to join our team in a hands-on role to discover the next generation of innovative cancer treatments.

Responsibilities for the role include:

– Independent generation of protein reagents (construct design/engineering, cloning, expression, purification, and characterization) using relevant expression systems to support mechanistic biochemical studies of potential drug targets

– Development of target-specific protein strategy in concert with multidisciplinary project teams

– Analysis, interpretation, documentation and presentation of data to cross-functional groups

– Contribution to group knowledge and expertise through collaboration and idea exchange with multidisciplinary teams

– Interest in developing additional skills in biochemical assay development, enzymology and/or mechanism of action studies

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements

– BA/BS or MS degree in Biochemistry, Biophysics, Structural Biology or a related field with 7+ years of relevant experience or Ph.D. with 3+ years of relevant experience

– Extensive knowledge of molecular biology, protein expression (E. coli, baculovirus and mammalian expression systems) and protein purification; demonstrated success in purification of diverse protein classes and/or multi-protein complexes

– Experience with AKTA Pure, Explorer or other similar FPLC is a must.

– Protein analytical skills (e.g. gel electrophoresis, Western blotting, and size exclusion chromatography) are required

– Experience with protein characterization techniques such as SEC-MALS, DLS, DSF, CD, peptide mapping by LC/MS/MS, post translational modification identification, etc. is required

– Demonstrated ability to independently analyze, interpret and present data in a clear manner

– Excellent communication and inter-personal skills

At NIBR we believe that along with our scientists, our culture is our greatest asset. To drive that culture each employee is expected to function in an innovative and collaborative manner. Each successful candidate will be able to demonstrate how they have functioned in this manner to drive results.